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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Workplace exposure summary
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Cited experiment was summarized in the National Toxicology Program-Center for the Evaluation of Risks to Human Reproduction Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane; original study was not reviewed
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane
Author:
NTP-CERHR
Year:
2003

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2-bromopropane
EC Number:
200-855-1
EC Name:
2-bromopropane
Cas Number:
75-26-3
Molecular formula:
C3H7Br
IUPAC Name:
2-bromopropane

Results and discussion

Applicant's summary and conclusion

Conclusions:
Female and male worker exposure to 2-bromopropane resulted in secondary amenorrhea and reduced germ cell function, respectively. These results support the laboratory studies that indicated 2-bromopropane reprotoxicity.