Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

The Nicotinamide toxicokinetic assessment is based on a weight of evidence approach. Following references were included: 
- EC Scientific Committee on Food (2002) Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic acid and Nicotinamide (Niacin)
- EFSA Panel on Additives and Products or Substances used in Animal Feed (2012) Scientific Opinion on the safety and efficacy of Niacin (Nicotinic acid and Nicotinamide) as a feed additive for all animal species. EFSA Journal 10(7): 2781.
- FDA 21CFR184.1535 (1979)
- OECD SIDS Report 3-Pyridinecarboxamide (Nicotinamide, 2002)
- UK Food Standards Agency Expert Group on Vitamins and Minerals (2003) Safe Upper Levels for Vitamins and Minerals.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information