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EC number: 205-399-7 | CAS number: 140-11-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology and carcinogenesis of benzyl acetate (CAS NO. 140-11-4) in F344/N rats and B6C3F1 mice (gavage studies)
- Author:
- Abdo, K. et al
- Year:
- 1 986
- Bibliographic source:
- National Toxicology Program, Publication No. 86-2506, USA, 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Male and female F344/N rats were obtained from Frederick Cancer Research Center and observed for 7 days before the test began. Animals were approximately 5 weeks old when placed on study, Groups of five rats of each sex were administered a single dose of benzyl acetate (250, 500, 1,000, 2,000, or 4,000 mg/ kg body weight) in corn oil by gavage. No controls were used. All animals were examined twice daily for clinical signs and mortality during the 15-day observation period. Animals were housed five per cage and received water and feed ad libitum during the observation period. Necropsies were not performed.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzyl acetate
- EC Number:
- 205-399-7
- EC Name:
- Benzyl acetate
- Cas Number:
- 140-11-4
- Molecular formula:
- C9H10O2
- IUPAC Name:
- benzyl acetate
- Reference substance name:
- alpha-acetoxytoluene; benzyl ethanoate; acetic acid, benzyl ester
- IUPAC Name:
- alpha-acetoxytoluene; benzyl ethanoate; acetic acid, benzyl ester
- Details on test material:
- - Name of test material (as cited in study report): Benzyl Acetate
- Physical state: water-white liquid with a pear-like odor
- Other:
Melting Point: -5100C
Boiling Point: 213 C
Vapor Pressure: 1.99 mm Hg at 60'C
Density: 1.05
Refractive Index: 1.4998
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Benzyl Acetate
- Physical state: water-white liquid with a pear-like odor
- Other:
Melting Point: -5100C
Boiling Point: 213 C
Vapor Pressure: 1.99 mm Hg at 60'C
Density: 1.05
Refractive Index: 1.4998
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Frederick Cancer Research Center Frederick. M D
- Age at study initiation: 5 weeks
- Housing: Bedding: Beta-Chips heat treated hardwood chips
Cages: Polycarbonate
Cage filters: Spun-bonded polyester filters
- Diet (e.g. ad libitum): Wayne Lab-Blox Allied Mills. ad libitum
- Water (e.g. ad libitum): Tap water supplied through automatic watering system. ad libitum
- Acclimation period: 1 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23
- Humidity (%): 40-60
- Air changes (per hr): 15
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Male and female rats: 250, 500, 1,000, 2,000 or 4,000 mg/kg body weight in corn oil
- Amount of vehicle (if gavage): 5 ml/kg for rat
- Justification for choice of vehicle: No data
MAXIMUM DOSE VOLUME APPLIED: 4,000 mg/kg body weigh - Doses:
- Male and female rats: 250, 500, 1,000, 2,000 or 4,000 mg/kg body weight in corn oil
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Necropsy of survivors performed: no
- Other examinations performed: Observed twice daily for mortality and clinical signs - Statistics:
- No data
Results and discussion
- Preliminary study:
- No applicable
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals that received benzyl acetate at 4,000 mg/ kg body weight were inactive within 2 hours after dosing, and 4/5 males and 2/5 females in these groups died (all on day 2).
- Clinical signs:
- other: All animals that received benzyl acetate at 4,000 mg/ kg body weight were inactive within 2 hours after dosing. No other compound-related clinical signs were observed
- Gross pathology:
- No data
- Other findings:
- No further data
Any other information on results incl. tables
No further data
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 for Benzyl acetate was found to be above 2000 mg/kg body weight in rats. According to Regulation (EC) No. 1272/2008, no classification is warranted.
- Executive summary:
Male and female F344/N rats were obtained from Frederick Cancer Research Center and observed for 7 days before the test began. Animals were approximately 5 weeks old when placed on study, Groups of five rats of each sex were administered a single dose of benzyl acetate (250, 500, 1,000, 2,000, or 4,000 mg/ kg body weight) in corn oil by gavage. No controls were used. All animals were examined twice daily for clinical signs and mortality during the 15-day observation period. Animals were housed five per cage and received water and feed ad libitum during the observation period. Necropsies were not performed. The LD50 for Benzyl acetate was found to be above 2000 mg/kg body weight in rats. According to Regulation (EC) No. 1272/2008, no classification is warranted.
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