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Description of key information

LD50 (oral) > 2500 mg/kg bw (2000 mg/kg tested, no effects observed). 
LD50 (dermal) > 2000 mg/kg bw.

Key value for chemical safety assessment

Additional information

In an acute oral toxicity study according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method), 6 female Sprague-Dawley rats were exposed to 2000 mg/kg bw. No clinical signs were observed. Although the highest dose tested were 2000 mg/kg bw the study director concluded the LD50 to be >2500 mg/kg as no deaths occurred (ISOPA Brussels, 2002a).

In an acute dermal toxicity study according to OECD Guideline 402 (Acute Dermal Toxicity), 5 male and 5 female Sprague-Dawley rats were exposed to 2000 mg/kg bw. No clinical signs were observed, resulting in a LD50 > 2000 mg/kg bw (ISOPA Brussels, 2002b).

Justification for classification or non-classification

Findings from acute toxicity testing do not warrant classification.