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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: 3 days
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summary report

Data source

Reference
Reference Type:
publication
Title:
Actions & interactions: Glycidyl ethers.
Author:
Lane JM
Year:
1980
Bibliographic source:
Veterinary and human toxicology 22(2): 99-101

Materials and methods

Principles of method if other than guideline:
Male rats were exposued to allyl glycidyl ether via intramuscular injections (400 mg/kg bw) on 3 consecutive days and subjected to lymphoid tissue examination.
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Allyl Glycidyl Ether

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intramuscular
Vehicle:
not specified
Duration of treatment / exposure:
3 days
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
400 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

2 out of 3 showed atrophy or loss of lymphoid tissue and decreased leucocyte count. The same report summarized results for other glycidyl ethers showing similar results indicating a class effect.

Applicant's summary and conclusion