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Toxicity to birds

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Description of key information

DCDPS poses no concern with regard to avian toxicity.

Key value for chemical safety assessment

Additional information

Experimental studies on the avian toxicity of DCDPS are not available. However, a study on wild observations in white-tailed sea eagle showed no correlation between reproductive parameters and DCDPS concentrations in eggs. The avian toxicity can be assessed on the basis of the derived PNECoral, food.

Some literature has been published regarding structurally similar compounds and their toxicity to birds, therefore some argumentations for a tentative read across are given below.

Schafer et al (1983) investigated the acute oral toxicity, repellency, and hazard potential of Dapsone (CAS 80-08-0) and Sulphenone(CAS 80-00-2) that can be considered supporting substances for assessment on DCDPS because of their structural analogy and thus suitable for read-across. Both the compounds did show low acute toxic potential falling into the nonhazardous class.In conclusion the absence of acute toxicity of Sulphenone indicates that acute toxic avian effects for DCDPS are unlikely.

Further read-across can be made from observations with the structural analogue Tetradifon (CAS 116-29-0),.Hill et al.,1995 reports TetradifonTetradifonexhibited a NOEC/EC10of 5000 mg/kg diet. Moreover,HSDB (2005b) and WHO (1986) assess Tetradifon as relatively non-toxic for birds on the basis of these figures. In conclusion the lacking subacute toxicity of Tetradifon indicates, that subacute toxic avian effectsfor DCDPS are unlikely.

Basing on the above attempted read acrossit can be concluded thatDCDPS poses no concern with regard to avian toxicity, thereforeit is considered unuseful to carry out further studies on birds.

References:

Schafer EW, Bowles WA & Hurlbut J (1983). The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds. PMID: 6882015, Arch. Environ. Contam. Toxicol. 12(3):355-82.

Hill EF, Heath RG,Spann JW & Williams JD (1975). Lethal dietary toxicities of environmental pollutants to birds. DC, U.S. Fish and Wildlife Service, Washington D.C., Special Scientific Report- Wildlife No. 191, 61 pp

HSDB 2005 b. HSDB Hazardous Substances Data Bank. A database of the U.S. National Library of Medicine's TOXNET system; http://toxnet.nlm.nih.gov; Version information: Complete Update on 2005-11-14

WHO World Health Organisation (1986). Tetradifon. Environ Health Criteria 67:20.