Registration Dossier
Registration Dossier
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EC number: 233-237-5 | CAS number: 10099-58-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines of the Federal Hazardous Substances Act (1973) and Title 49-Transportation Section 173.240
- GLP compliance:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): C-500 (Rare Earth Chloride)
- Molecular formula: LaCl3
- Physical state: powder
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- The powder was mixed with distilled water to form an aqueous paste; pH of the aqueous paste measured prior to application: 5.2 - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- - Prior to application of the sample, the backs were clipped free of hair. The skin was left intact.
- area of exposure: 1 inch square on each rabbit
- Patches of surgical gauze measuring 1 inch square, 2 layers thick, were applied over the samples and covered with a non-reactive tape. The rabbits were then wrapped with a rubber dam.
- After the 4 h exposure, the dam and tape were removed and the skin reactions evaluated (no washing). After 72 h a second evaluation was made.
- Reactions were scored according to the methods described in the Federal Hazardous Substance Act.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 4 h and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 4 h and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No reactions after 4 h and 72 h.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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