Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
23.5 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
75
Modified dose descriptor starting point:
NOAEC
Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
3.3 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

The following DN(M) EL did not need to be calculated/derived: 

- Dermal DN(M) EL for acute/short-term exposure - systemic effects: Acute dermal toxicity study lacked (relevant) effects.

- Inhalation DN(M) EL for acute/short-term exposure - systemic effects: Test substance has a relatively low vapor pressure and inhalatory exposure to this substance should not be a concern. Furthermore, acute toxicity studies by the oral and dermal routes lacked effects.

- Dermal DN(M)EL for acute/short-term exposure - local effects: Taking a qualitative approach, effects such as sensitization are not relevant based on (no) residual likelihood of risk. The test substance will only be shipped into the EU as a residual component of a reaction mix, at a residual concentration of less than 1 wt. %. In addition, the potential for exposure to this substance is essentially zero based upon RMM and OC in the workplace, and it only demonstrates moderate sensitization potential (Table R.8-23). As DNELs sensitisation can not be applied consistently based on the nature of sensitisation data (i.e., guinea pig results), conventional practices and RMM are considered adequate and effective, without determination of a threshold benchmark.

- Inhalation DN(M) EL for acute/short-term exposure - local effects: Test substance has a relatively low vapor pressure and inhalatory exposure to this substance should not be a concern.

- Dermal DN(M) EL for long-term exposure - local effects: Acute dermal toxicity study lacked (relevant) effects.

- Inhalation DN(M) EL for long-term exposure - local effects: Test substance has a relatively low vapour pressure and inhalatory exposure to this substance should not be a concern.

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

The following DN(M) EL did not need to be calculated/derived. There will be no exposure to the test substance and no residual likelihood of risk. The general population will not come into contact with test substance. Subsequent consumer products will not be C&L for potential health hazards, and residual concentrations in such products are non-detectable.

- Dermal DN(M) EL for acute/short-term exposure - systemic effects

- Inhalation DN(M) EL for acute/short-term exposure - systemic effects

- Oral DN(M) EL for acute/short-term exposure - systemic effects

- Dermal DN(M) EL for acute/short-term exposure - local effects

- Inhalation DN(M) EL for acute/short-term exposure - local effects

- Dermal DN(M) EL for long-term exposure - systemic effects

- Inhalation DN(M) EL for long-term exposure - systemic effects

- Oral DN(M) EL for long-term exposure - systemic effects

- Dermal DN(M) EL for long-term exposure - local effects

- Inhalation DN(M) EL for long-term exposure - local effects