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Registration Dossier
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EC number: 205-594-7 | CAS number: 143-24-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC, Daphnia magna: 320 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 320 mg/L
Additional information
Under 13.2 attached is the justification for read across to existing data from diethylene glycol dimethyl ether (Diglyme, CAS 111-96-6) as an appropriate source molecule. It is hypothesized that diglyme can be used as analogue to tetraglyme, because they share the same toxic mode of action so that read across among each other can be used to assess the acute aquatic toxicity of the individual members.The appropriateness of the chosen source molecule is based on structural and functional similarities, comparable physicochemical properties, common metabolic pathway(s), and a similar mode of action indicating a comparable ecotoxicological profile for tetraglyme as the target substance and diglyme as the source substance.
One read across key-study is available for the source substance diglyme with Daphnia magna for chronic toxicity to daphnia (21 d). The determined NOEC was 320 mg/L. All results are shown in the "short description of key information" field.
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