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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

From Read across source substance Triglyme: LC50, Danio rerio: > 5000 mg/L

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
Effect concentration:
> 5 000 mg/L

Additional information

Under 13.2 attached is the justification for read across to existing data from triethylene glycol dimethyl ether (Triglyme, CAS 112-49-2) as an appropriate source molecule. It is hypothesized that triglyme can be used as analogue to tetraglyme, because they share the same toxic mode of action so that read across among each other can be used to assess the acute aquatic toxicity of the individual members.The appropriateness of the chosen source molecule is based on structural and functional similarities, comparable physicochemical properties, common metabolic pathway(s), and a similar mode of action indicating a comparable ecotoxicological profile for tetraglyme as the target substance and triglyme as the source substance.

The read across key-study from Triglyme with Danio rerio is available for acute toxicity to fish. The  LC50 determined was > 5000 mg/L.