Registration Dossier
Registration Dossier
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EC number: 205-594-7 | CAS number: 143-24-8
Endpoint summary
Administrative data
Description of key information
Additional information
Justification for Read across to other Glymes
Monoglyme (CAS No. 110 -71 -4 ), Diglyme (CAS No. 111 -96 -6) and Triglyme (CAS No. 112 -49 -2) are already registered under REACH. These substances are chain homologues of the registration substance Tetraglyme (CAS No. 143 -24 -8). All these Glymes which differ in their structure by the number of the repeating group OCH2CH2 (n=1 -4) have very low acute and chronic ecotoxicity which are in most cases in the same order of magnitude. For Tetraglyme the acute and chronic data from Di- and Triglyme were used for read across.To confirm acceptability of the read across acute daphnia and algae tests were carried out for Tetraglyme. In the table below all available acute an chronic ecotoxicity studies for Glymes are summarized to demonstrate the applicability of the read across.
| SPECIES | GUIDELINE | ENDPOINT | MONOGLYME | DIGLYME | TRIGLYME | TETRAGLYME |
| mg/L | mg/L | mg/L | mg/L | |||
| Acute Fish | OECD 203 | LC50 (96h) | >5000 (Tri-G) | >5000 (Tri-G) | >5000 | >5000 (Tri-G) |
| Acute Daphnia | OECD 202 | EC50 (48h) | 4000 | 943 | >5000 | 7467 |
| Algae | OECD 201 | ErC50 (72h) | 9120 | >10,000 | >6000 | 8996 |
| Microorganisms | OECD 209 | EC50 (3h) | >6400 | >5000 | >5000 | >5000 (Tri-G) |
| NOEC (3h) | 200 | 1067 | >5000 | >5000 (Tri-G) | ||
| Chronic Daphnia | OECD 211 | NOEC (21d) | 320 (Di-G) | 320 | 320 (Di-G) | 320 (Di-G) |
| Algae | OECD 201 | ErC10 (72h) | 3793 | 8318 | 3000 | 2871 |
(Di-G) means read across from Digylme, (TriG) means read across from Triglyme
SHORT-TERM TOXICITY
For Tetraglyme short-term aquatic ecotoxicity studies for all three trophic levels (fish, daphnia and algae) are available as well as studies on sludge respiration inhibition.
| Fish: | OECD 203 | LC50 (96h) | > 5000 mg/L | Read across Tri-G |
| Daphnia: | OECD 202 | EC50 (48h) | 5000 mg/L | Key Study |
| Algae: | OECD 201 | ErC50 (72h) | 8996 mg/L | Key Study |
| Microorganisms (Sludge) | OECD 209 | NOEC (3h) | > 5000 mg/L | Read across Tri-G |
| EC50 (3h) | > 5000 mg/L | Read across Tri-G |
Tri-G means Trigylme
The short-term ecotoxicity data were used for the derivation of the PNEC aqua intermittent release (see Section 6 Tetraglyme PNEC).
LONG-TERM TOXICITY
Read across from Diglyme 21d Daphnia study
For reasons given in the waiving statements Section 6.1.2 no long-term fish toxicity tests were carried out. Instead a Diglyme long-term invertebrate study with daphnia was established. This 21d daphnia study with Diglyme (REACH Registration No. 01-2119485900-34-0000) was used for read across to Tetraglyme (see Section 6.1.4) for justification.
| Algae: | OECD 201 | ErC10 (72h) | 2871 mg/L | Key Study |
| Daphnia: | OECD 211 | NOEC (21d) | 320 mg/L | Read Across from Diglyme |
The algae ErC10 (72h) and the daphnia NOEC (21d) were used to derive the PNEC aqua for continous release (see Section 6 Tetraglyme PNEC).
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