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Diss Factsheets
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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- data not available
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-standard study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of chronic salicylate on GABAergic activity in rat inferior colliculus
- Author:
- Bauer CA Brozoski TJ, Holder TM, Caspary DM
- Year:
- 2 000
- Bibliographic source:
- Hearing Research, 147, 175-182.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- no data available
- IUPAC Name:
- no data available
- Details on test material:
- "Salicylate"
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: between 7 and 12 weeks
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: individually in cage
- Diet : no data
- Water : no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- not specified
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 months (animals behaviorally tested for evidence of tinnitus)
4 weeks (animals not behaviorally tested for evidence of tinnitus) - Frequency of treatment:
- daily
- Post exposure period:
- no
Doses / concentrations
- Dose / conc.:
- 8 other: mg/ml
- Remarks:
- Basis: nominal in water
- No. of animals per sex per dose:
- 10 males per dose (behaviorally tested for evidence of tinnitus)
5 males per dose (no behaviorally tested for evidence of tinnitus) - Control animals:
- yes, concurrent no treatment
Examinations
- Examinations:
- The following parameters were observed: daily fluid consumption, weekly weights, serum salicylate levels, auditory brainstem response thresholds,
GAD (Glutamic Acid Decarboxylase) levels in the inferior colliculus and GABA receptor binding characteristics. - Positive control:
- no
Results and discussion
- Details on results:
- The serum salicylate level ranged from 9.89 to 38.2 mg/dL. No detectable levels of salicylate were present in control sera. The total mean daily dose of salicylic acid ingested by the subjects that were not behoviorally tested was 563.2-661 mg/kg/d. The weight of the subject was stable throughout the duration of the study. Auditory brainstem response testing revealed a 3.8 dB difference in the
mean threshold. Western blotting revealed a significant 63% (p < 0.008) elevation of GAD levels in the inferior colliculus (IC) ofsalicylate-treated
subjects. GAD expression and GABAa receptor binding characteristics may be altered with chronic exposure to sodium salicylate and these changes may represent aberrant plasticity clinically experienced as tinnitus.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.