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EC number: 482-330-9 | CAS number: 144020-22-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- and EEC Methods for the determination of toxicity. Annex to Commission Directive 2004/73/EC (Official Journal No. L152, 30.4.2004), Part B, Method B.42.
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- -
- EC Number:
- 482-330-9
- EC Name:
- -
- Cas Number:
- 144020-22-4
- Molecular formula:
- C17H26O
- IUPAC Name:
- 1-[(1E,5Z,9Z)-2,5,10-trimethylcyclododeca-1,5,9-trien-1-yl]ethan-1-one; 1-[(1R)-2,5,10-trimethylcyclododeca-2,5,9-trien-1-yl]ethan-1-one; 1-[(1R)-4,9-dimethyl-12-methylidenecyclododeca-4,8-dien-1-yl]ethan-1-one; 1-[(1S)-2,5,10-trimethylcyclododeca-2,5,9-trien-1-yl]ethan-1-one; 1-[(1S)-4,9-dimethyl-12-methylidenecyclododeca-4,8-dien-1-yl]ethan-1-one
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- concentrations of 10, 25 and 50% v/v in Acetone : Olive Oil (4:1 v/v)
- No. of animals per dose:
- four
Results and discussion
- Positive control results:
- Positive control study with hexyl cinnamic aldehyde using the local lymph node assay (Study No. HLS/0521). This study was performed to confirm the sensitivity and reliability of the experimental technique used at Huntingdon Life Sciences to detect skin sensitization potential. The study was performed using the murine local lymph node assay and a known moderate sensitizer - hexyl cinnamic aldehyde (HCA) [Technical grade 90.6%] supplied by Aldrich Chemical Co, England (Batch No. 13102MO, Expiry 13 June 2007).
This positive control study was conducted between 24 May and 6 June 2007 using sixteen mice of the CBA/Ca strain supplied by Harlan UK Ltd., Bicester, Oxon, England. Groups of four mice were used in this study. Three dosage levels and a vehicle control were used with dosages of HCA selected based on previous experience with HCA at this laboratory as follows: 10, 25 and 50% v/v in AOO (4:1 v/v acetone:olive oil)
The positive control study is considered to be valid if at least one concentration of HCA results in a threefold greater increase in 3H-methyl thymidine (3HTdR) incorporation compared to control values.
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- Results for each treatment group were expressed as the stimulation index. This was obtained by comparing the proliferation in the vehicle treated control group with the values from the three test groups as follows: the ratio of 3HTdR incorporation into lymph node cells, expressed as dpm, relative to that recorded for control lymph nodes is derived for each test group based on the group mean dpm per node. When the stimulation index ≥3, the test substance is regarded as a skin sensitizer.
Applicant's summary and conclusion
- Interpretation of results:
- other: Potentially weak skin sensitizer
- Conclusions:
- Trimofix O is regarded as a potential weak skin sensitizer, at the concentration of 25%, with an EC3 value of 20.71. (Kimber et al, 2003).
- Executive summary:
Trimofix O is regarded as a potential weak skin sensitizer, at the concentration of 25%, with an EC3 value of 20.71. (Kimber et al, 2003).
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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