Registration Dossier
Registration Dossier
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EC number: 222-429-4 | CAS number: 3468-63-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- EC Number:
- 222-429-4
- EC Name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- Cas Number:
- 3468-63-1
- Molecular formula:
- C16H10N4O5
- IUPAC Name:
- 1-[(2,4-dinitrophenyl)diazenyl]-2-naphthol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Gelb-Silber
Test system
- Vehicle:
- other: Sesame oil
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- Single exposure of 0.1 mL of 5 or 10% suspension of C.I. Pigment Orange 5 in sesame oil
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 3 to 7 hours
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Very slight redness after 3 to 7 hours was observed for three rabbits exposed to the highest concentration of 10% of C.I. Pigment Orange 5 in Sesame oil. The redness was not observed after 24 hours, and the rabbit of 5% dilution showed no reaction.
- Other effects:
- Very slight redness after 3 to 7 hours was observed for three rabbits exposed to the highest concentration of 10% of C.I. Pigment Orange 5 in Sesame oil. The redness was not observed after 24 hours, and the rabbit of 5% dilution showed no reaction.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
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