Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient experimental details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
inhalation of an atmosphere enriched with of the test item at room temperature. For enrichment 200 l air/h are conducted through a 5 cm layer of the test item.
GLP compliance:
no
Remarks:
prior to implementation of GLP
Test type:
other: acute inhalation risk test
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2'-methoxyacetoacetanilide
EC Number:
202-131-0
EC Name:
2'-methoxyacetoacetanilide
Cas Number:
92-15-9
Molecular formula:
C11H13NO3
IUPAC Name:
N-(2-methoxyphenyl)-3-oxobutanamide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
The test was performed with respect to H.F Smyth et al in Am. Ind. Hyg. Ass. J. (23), 95-107, 1962

Administration / exposure

Route of administration:
other: inhalation: fugative amount of the solid test item
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
inhalation of an atmosphere enriched with a fugative amount of the test item at room temperature. For enrichment 200 l air/h are conducted through a 5 cm layer of the test item. Exposure perid: 7h. Observation time at 3, 10, and 30 min, and 1, 3, and 7 h after beginning of treatment.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 7 h
Concentrations:
no data
No. of animals per sex per dose:
12
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: lethality
Effect level:
other: enriched atmosphere, conc. not specified
Based on:
other: fugative amounts of the solid test item
Exp. duration:
7 h
Remarks on result:
other: no lethality
Mortality:
0/12
Clinical signs:
other: no abnormalities
Gross pathology:
no abnormalities
Other findings:
no other findings

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Under the test conditions the test item showed no signs of inhalative toxicity.
Executive summary:

Under the test conditions the test item showed no signs of inhalative toxicity.