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Diss Factsheets
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EC number: 203-401-0 | CAS number: 106-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology and carcinogenesis studies of p-chloroaniline hydrochloride (CAS no. 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies)
- Author:
- NTP
- Year:
- 1 989
- Bibliographic source:
- U.S. department of health and human services Public Health Service National Institutes of Health National toxicology program Technical Report Series No. 351
- Reference Type:
- review article or handbook
- Title:
- 4-CHLOROANILINE
- Author:
- IPCS-INCHEM
- Year:
- 2 003
- Bibliographic source:
- in: Concise International Chemical Assessment Document 48
Materials and methods
- Principles of method if other than guideline:
- Groups of five rats of each sex were administered 25, 50, 100, 200, or 400 mg/kg p-chloroaniline by gavage in aqueous hydrochloric acid, 5 days per week for a total of 12 doses over 16 days. Vehicle controls received deionized water by gavage. A necropsy was performed on all animals.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-chloroanilinium chloride
- EC Number:
- 243-656-5
- EC Name:
- 4-chloroanilinium chloride
- Cas Number:
- 20265-96-7
- IUPAC Name:
- 4-chloroanilinium chloride
- Reference substance name:
- p-chloroaniline hydrochloride
- IUPAC Name:
- p-chloroaniline hydrochloride
- Details on test material:
- - Name of test material (as cited in study report): p-chloroaniline hydrochloride
- Physical state: solid
- Analytical purity: p-Chloroaniline (99% pure) was used to prepare p-chloroaniline hydrochloride solutions for administration to animals.
- Lot/batch No.: 127
- Stability under test conditions: the chemical was found to be stable in water for at least 14 days at room temperature
- Storage condition of test material: room temperature
- Other: the chemical was found to be stable in water for at least 14 days at room temperature dose mixtures were prepared at weekly intervals, placed in foil wrapped containers, and refrigerated until the day of dosing.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: deionized water
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 16 days
- Frequency of treatment:
- 5 days per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 25, 50, 100, 200, or 400 mg/kg of body weight.
Basis:
actual ingested
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
Examinations
- Sacrifice and pathology:
- Necropsy performed on all animals; histologic exams performed on 2 males and 2 females in the vehicle control and 100 mg/kg groups. Tissues examined include: adrenal glands, bone marrow, brain, colon, esophagus, heart, jejunum, kidneys, liver, lungs and mainstem bronchi, mandibular lymph nodes, pancreas, parathyroid glands, pituitary gland, prostate/ testes or ovaries/uterus, regional lymph nodes, salivary glands, skin, spleen, stomach, thymus, thyroid gland, tissue masses, trachea, and urinary bladder. Spleen examined from 2 males and 2 females in the 25 mg/kg groups.
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
In the 16-day studies, male and female rats received 25, 50, 100,200, or 400 mg/kg of body weight. The vehicle controls received deionized water.
All rats that received 200 or 400 mg/kg died during the first 6 days of the studies. Splenic enlargement was observed at necropsy in rats administered 25, 50, or 100 mg/kg. Congestion of the spleen and hemosiderin deposition in the renal cortical tubular epithelial cells were observed at 100 mg/kg in male and female rats
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.