Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

According to REACH regulation Annex XI, the conduct of a study is scientifically unjustified. As outlined in TGD R 7c, the uptake of many types of dissolved inorganic ions (particularly metals) largely depend on the presence of specific active transport systems. These systems are regulated by saturable kinetics, and the degree of uptake of a particular ion will also be strongly influenced by ligand binding and competitive interactions at the receptor site. As a result of these processes, organisms may actively accumulate some inorganic substances to meet their metabolic requirements if environmental concentrations are low (leading to a high BCF). At higher concentrations, organisms with active regulation mechanisms may even limit their intake and increase elimination and/or storage of excess substance (leading to lower BCFs). For classification purpose data are not required and furthermore metals are currently outside the scope of PBT assessments.