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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: non-GLP study (short report)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD401
Deviations:
yes
Remarks:
intraperitoneal application
Principles of method if other than guideline:
Acute toxicity study after i.p. application in rats.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid - liquid: suspension

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Doses:
64, 80, 86, 100, 125 and 140 mg/kg
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
98 mg/kg bw
Based on:
test mat.
Sex:
male/female
Dose descriptor:
LD50
Effect level:
68 mg/kg bw
Based on:
act. ingr.
Clinical signs:
Reduced activity, laboured breathing, dyspnoe, tremor, convulsion, prone position and tumbling
Gross pathology:
Findings of toxicological importance and for toxicological evaluation can be summarized as follows:
Animals sacrificed at the end of the observation period: low perihepatitis and a slight hepatomegaly.
Animals succumbing during the observation period: catarrh and gastroenteritis.
Other findings:
First exitus after 2 hours, last exitus after 4 days.

Applicant's summary and conclusion

Conclusions:
Study describes possible target organs of a repeat-dose study with the active ingredient thioglycolate. Study not used for C & L. Under the experimental conditions, the LD50 i. p. of CaTG is 98 mg/kg.