Registration Dossier
Registration Dossier
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EC number: 218-679-9 | CAS number: 2215-35-2
Endpoint summary
Administrative data
Description of key information
The test material is not acutely toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 230 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 0.002 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 25 000 mg/kg bw
Additional information
This substance cause moratlity and clinical signs of toxicity via the oral route of exposure in animals when tested in accordance with 16CFR 1500.3 which is similar to OECD Guideline 401. The rat oral LD50 is 2,230 mg/kg in male rats. Sublethal effects of lethargy, diarrhea, and piloerection were observed. Necropsy observations included lung and gastrointestinal abnormalities, but no specific organ toxicity. Body weights of the survivors were within normal ranges.
This substance does not show adverse toxicity effects via the dermal route of exposure in animals when tested in accordance with 40CFR 163.81 -1, 1978 modified in accordance with EPA Pesticide Assessment Guidelines November 1982. The rat dermal LD50 is greater than 25,000 mg/kg in rabbits. No mortality occurred. Clinical signs included dew face, yellow nasal discharge, alopecia, emaciation, lethargy, and ptosis. Skin reactions generally were moderate on day 1 following administration and worsened during the course of the study with the formation of severe eschar accompanied by moderate to severe edema. All survivors lost weight. No specific organ toxicity is evident.
The inhalation LC50 was determined to be greater than 2 mg/l (0.002 mg/m3) in male rats using a method similar to OECD 403. Clinical signs included sniffing and grooming during the exposure period, eye irritation, oily hair stuck together, and swollen heads and faces. Dark areas in the lung of one animal was noted. Body weights were not affected. No specific organ toxicity was observed.
Justification for classification or non-classification
In accordance with EU CLP (Regulation (EC) No. 1272/2008), classification of this substance is not required for acute toxicity.
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