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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
EC Number:
404-310-0
EC Name:
Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
Cas Number:
10591-85-2
Molecular formula:
C30H28N2S4
IUPAC Name:
N,N-dibenzyl[(dibenzylcarbamothioyl)disulfanyl]carbothioamide

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: strains TA 98, TA 100, TA 1535, TA 1537, TA 1538
Metabolic activation:
with and without
Metabolic activation system:
Arochlor-induced rat liver
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation): CA 24,69 .. , CA 2000 µg/plate
Concentration range in the main test (without metabolic activation): CA 24,69 ,.. CA 2000 µg/plate
Vehicle / solvent:
Solvent: DMSO
Details on test system and experimental conditions:
Concentration of the test substance resulting in precipitation: 2000 µg/plate

Results and discussion

Additional information on results:
Observations:
No signs of toxicity at any concentration tested,
No reduction of background bacterial lawn at any concentration.
Positive controls gave the expected strong increase in the number of S9+ and S9- revertants,

Any other information on results incl. tables

negative with metabolic activation

negative without metabolic activation

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation