Registration Dossier

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See endpoint summary for justification of read-across. ATMP acid is a member of the ATMP phosphonates category.
Cross-reference
Reason / purpose:
read-across source
Reference
Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
Application of radiolabelled substance and observation of absorption and excretion in urine.
GLP compliance:
not specified
Radiolabelling:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Vehicle:
water
Duration of exposure:
24 h
Doses:
200 µl of a 1% aqueous solution was applied to 10 cm² area of shaved skin.
No. of animals per group:
2 male, 2 female

absorption: 0.603% (male); 0.94% (female)

excretion: the majority of the absorbed radiolabelled ATMP was excreted in the urine within 24 hours of treatment.

Conclusions:
A neutralised solution of ATMP was tested for dermal absorption. It was concluded that absorption was very low (<1%) and that most of the absorbed substance was excreted in the urine.

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Results and discussion

Any other information on results incl. tables

absorption: 0.603% (male); 0.94% (female)

excretion: the majority of the absorbed radiolabelled ATMP was excreted in the urine within 24 hours of treatment.

Applicant's summary and conclusion