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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication available for review, generally well documented, meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
publication
Title:
Relationship between bone mineralization,|Ca absorption and plasma Ca in phosphonate-treated rats.
Author:
Treschel, U, Schenk, R, Bonjour, J-P, Russell, RGG and Fleisch, H
Year:
1977
Bibliographic source:
Am J Physiol, 232, E298 - 303

Materials and methods

Type of study / information:
Type: other: effects on bone

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Neutralised ATMP (equivalent to 10 mg ATMP/kg bwt) resulted in a non-significant 30% increase in the width of the
epiphyseal plate and inhibited mineralization of osteoid (n
= 4 animals). 

Uptake of 45Ca from ligated intestine was unaffected by
neutralised ATMP (P<0.001; n = 37 animals).

There was no significant effect on plasma calcium following
2, 3 or 7 s.c. treatments with neutralised ATMP. Plasma
phosphate was decreased (13%; P<0.05) after the second
injection only (i.e. on day 3, prior to treatment).

Applicant's summary and conclusion

Conclusions:
ATMP produced marginal effects on skeletal mineralization, and did not influence intestinal calcium uptake or plasma calcium values.