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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

A 96-h LC50 value of 160 mg/l has been determined for the effects of ATMP-H (CAS 6419-19-8) on mortality of Salmo gairdneri (now known as Oncorhynchus mykiss).

Key value for chemical safety assessment

LC50 for freshwater fish:
160 mg/L

Additional information

Reliable data on the short term toxicity of ATMP-xNa salts to freshwater fish are available. A 96 h LC50 value of >400-500 mg/L has been determined for the effects of ATMP-5Na salt on the mortality of the marine fish Cyprinodon variegatus. This corresponds to a 96 h LC50 value of >282 mg/L (as active ATMP acid) based on the active acid content (28.2%) reported in the test report. The study was conducted with ATMP-5Na (CAS 2235-43-0). The result is expressed in terms of active acid.

However, the lowest reliable value available for the category is found in a study with ATMP-H. A reliable 96 h LC50 value of 160 mg/L (as active acid) has been determined for the effects of ATMP-H (CAS 6419-19-8) on mortality of Salmo gairdneri (now known as Oncorhynchus mykiss). This value is taken from a 14 d study, where the 96 h LC50 was reported. The same study determined a 14 d NOEC of 47 mg active acid/L and a 14 d LC50 of 150 mg active acid/L with S. gairdneri (now known as O. mykiss) and ATMP-H (CAS 6419-19-8).

The results of tests conducted on ATMP and its salts are directly comparable, because the ionisation state will depend only on the pH of the test medium. The counterion is not considered to contribute to effects in fish. At environmentally-relevant pH values, ATMP will be ionised typically four or five times, and will form stable complexes with metal ions.

Here, the value of 160 mg equivalent active acid/L may be directly read-across.

The results have been read-across to ATMP sodium, potassium and ammonium salts in accordance with the rationale outlined in the Ecotoxicological information section of the IUCLID and Section 1.4 of the CSR.