Registration Dossier
Registration Dossier
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EC number: 200-020-1 | CAS number: 50-23-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Hydrocortisone does not contain any functional group, which is susceptible to hydrolytic degradation. Thus hydrolytic stability is to be expected. This is experimentally supported by the results of a experimental hydrolysis study with 21 -hydroxy-16 alpha-methyl-4 -pregnene-3,20 -dione, which differs in missing hydroxy groups in positions 11 and 17 an additional methyl group position 16, which was found to be hydrolytically stable in the pH region 4 to 9 (at 25 °C).
The same behaviour is to be expected for hydrocortisone.
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