Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Annex V, C7
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Dissipation half-life of parent compoundopen allclose all
pH:
4
Temp.:
50 °C
Half-life:
> 1 - < 365 d
pH:
7
Temp.:
50 °C
Half-life:
> 1 - < 365 d
pH:
9
Temp.:
50 °C
Half-life:
> 1 - < 365 d

Any other information on results incl. tables

Under the test conditions C24 was found to undergo significant hydrolysis as pH4 (100%), pH7 (46.7%) and pH9
(79.9%) after 5 days at 50 Deg C. The results indicate that at 25 Deg C, the half-life of C24 will be between 1 day and 1 year at pH 4, 7 and 9.

Applicant's summary and conclusion