Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via inhalation route
Dose descriptor:
NOAEC
18 000 mg/m³
Additional information

The key study for reproductive toxicity is the only available study for this endpoint. The study was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP, and was therefore assigned Reliability 1. A range-finding study is also available.


Short description of key information:
A combined repeat dose inhalation toxicity study and reproductive/developmental toxicity screening study was carried out for tetramethylsilane according to OECD 422 and in compliance with GLP (DCC, 2005). There were no adverse effects on general systemic, reproductive or developmental endpoints at the highest dose tested, 5000 ppm (ca. 18,000 mg/m3).

Effects on developmental toxicity

Description of key information
A combined repeat dose inhalation toxicity study and reproductive/developmental toxicity screening study was carried out for tetramethylsilane according to OECD 422 and in compliance with GLP (DCC, 2005). There were no adverse effects on general systemic, reproductive or developmental endpoints at the highest dose tested, 5000 ppm (ca. 18000 mg/m3). 
Effect on developmental toxicity: via inhalation route
Dose descriptor:
NOAEC
18 000 mg/m³
Additional information

The key study for developmental toxicity is the only available study for this endpoint. The study was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP, and was therefore assigned Reliability 1. A range-finding study is also available.

Justification for classification or non-classification

There are no data to suggest that tetramethylsilane should be classified for reproductive or developmental toxicity.