Registration Dossier

Administrative data

Description of key information

Reliable in vivo skin and eye irritation studies are available for tetramethylsilane, conducted according to OECD 404 and OECD 405, and in compliance with GLP (Huls, 1998c and Huls, 1998d). Tetramethylsilane was not an irritant to rabbit skin or eyes. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The key skin and eye irritation studies are the only data available for these endpoints (Huls, 1998c and Huls, 1998d). They were conducted in accordance with the appropriate OECD test guidelines and in compliance with GLP, and are therefore assigned Reliability 1.

Justification for classification or non-classification

Based on reliable in vivo data, tetramethylsilane is not classified as irritating to skin or eyes according to EU Directive 67/548/EEC and Regulation 1272/2008.