Registration Dossier
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EC number: 200-899-1 | CAS number: 75-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study, conducted according to OECD 401 and in compliance with GLP, the LD50 for male and female rats was >2000 mg/kg (Huls, 1998). Clinical symptoms were noticed 30 minutes to six hours after treatment. Abnormal gait, squatting position, sedation, paddling movements, piloerection, diarrhea and diuresis were observed. From day one until the end of the study (day 14) no other clinical signs were observed. No abnormalities were detected at necropsy.
In the acute inhalation study, conducted in accordance with OECD 403 and in compliance with GLP, the LC50 was determined to be >21.3 mg/l in male and female rats (Muijer, 1998). There were no mortalities or clinical signs of toxicity. Findings at necropsy consisted of abnormalities in the lungs, intestines and testes. Abnormalities of the lungs consisted of petechiae and/or hyalin spots or areas on one or more lobes in most animals. Pale discolouration of the lungs was seen in one male animal.
In the key acute dermal toxicity study, conducted according to OECD 402 and in compliance with GLP, the LD50 for male and female rats was determined to be >2000 mg/kg. (Huls, 1998). There were no clinical signs, signs of local irritation or abnormalities at necropsy.
Key value for chemical safety assessment
Additional information
The key acute oral and dermal toxicity studies (Huls, 1998a and Huls, 1998b) were the only available data for those endpoints. The studies were conducted in accordance with appropriate OECD test guidelines and in compliance with GLP, and were therefore assigned Reliability 1.
The key acute inhalation toxicity study (Muijer, 1998) was selected as the most reliable study available for this endpoint. It was conducted according to OECD 403 and in compliance with GLP, and was therefore assigned Reliability 1. An additional non-standard inhalation study is available in which the exposure duration was only 30 minutes.
Justification for classification or non-classification
Based on reliable measured data for the oral, inhalation and dermal routes, tetramethylsilane is not classified for acute toxicity according to EU Directive 67/548/EEC and Regulation 1272/2008.
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