Registration Dossier
Registration Dossier
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EC number: 200-899-1 | CAS number: 75-76-3
Endpoint summary
Administrative data
Description of key information
Additional information
The registered substance, tetramethylsilane (CAS 75-76-3; EC No. 200-899-1), is not susceptible to hydrolysis in contact with water and atmospheric moisture therefore tetramethylsilane is the relevant assessment entity for chemical safety assessment.
The substance is a highly volatile material with a very low boiling point. As a consequence, it is difficult to maintain exposure concentrations of the substance in aquatic toxicity test media. Preferred data for evaluating the aquatic hazard of the substance are therefore selected from studies that included steps designed to achieve stable exposure concentrations over the periods of the tests.
Short-term aquatic toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Scenedesmus subspicatus), with tetramethylsilane. The relevant short-term values are:
A 96-hour LC50 value of 1.9 mg a.i./l (measured concentration) has been determined for the effects of the test substance on mortality of Oncorhynchus mykiss under flow-through conditions in a temperature controlled closed system.
A 48-hour EC50 value of >103 mg/l (arithmetic mean measured concentration) has been determined for the effects of the test substance on mobility of Daphnia magna. The test organisms were exposed to the substance in headspace containers that were sealed with a septum.
A 72-hour EC50 value of >0.0079 mg/l and NOEC of ≥0.0079 mg/l (geometric mean measured concentration) have been determined for the effects of the test substance on growth rate of Scenedesmus subspicatus. The test organisms were exposed to the substance in vessels that were secured with rubber septa and crimp-top caps to minimise volatilisation.
Data waivers are applicable to long-term toxicity to fish and aquatic invertebrates.
Toxicity to microorganisms: A 17-hour EC50 value of 3342 g/l and an EC10 value of 17.1 g/L have been determined in a growth inhibition study with Pseudomonas putida (DIN 38412-8, Pseudomonas putida).
Refer to IUCLID Section 6 endpoint summary, CSR Section 7.0, for further discussion of the approach to chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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