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EC number: 238-034-5 | CAS number: 14177-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 May - 23 May 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: EU-Method B.46 (in vitro skin irritation: reconstructed human epidermis model test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline for the testing of chemicals. Draft proposal for a new guideline. In vitro skin irritation: human skin model test, December, 2007
- Deviations:
- yes
- Remarks:
- Interleukin-1 alpha was not determined
- Principles of method if other than guideline:
- The skin irritancy potenial of nickel hydrogencitrate was tested by using the human skin model EPISKIN and measurement of cell viability by dehydrogenase conversion of MTT into a blue formazan salt.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55116 Mainz, Germany
Test material
- Reference substance name:
- Molybdenum nickel tetraoxide
- EC Number:
- 238-034-5
- EC Name:
- Molybdenum nickel tetraoxide
- Cas Number:
- 14177-55-0
- Molecular formula:
- MoO3*nNiO (with n in a range of 0.6 - 1)
- IUPAC Name:
- Reaction mass of molybdenum oxide and nickel oxide
- Reference substance name:
- 238-034-0
- IUPAC Name:
- 238-034-0
- Details on test material:
- - Name of test material (as cited in study report): Molybdenum nickel tetraoxide
- Molecular formula: NiMoO4
- Physical state / appearance: light yellow powder
- Analytical purity: >99%
- Lot/batch No.: GRA20100315
- Expiration date of the lot/batch: Feb 2012
- Storage conditions: Room temperature 20 +/- 5°C
Constituent 1
Constituent 2
Test animals
- Species:
- other: in vitro test: human skin
- Strain:
- other: in vitro test: human skin
Test system
- Type of coverage:
- other: in vitro test: human skin model test
- Preparation of test site:
- other: in vitro test: human skin model test
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Tissue 1: 26.6 mg; Tissue 2: 25.7 mg; Tissue 3: 24.6 mg
and wetted with 25 µL DPBS (Dulbecco's Phophate Buffered Saline) buffer - Duration of treatment / exposure:
- not applicable: see "any other information on materials and methods"
- Observation period:
- not applicable: see "any other information on materials and methods"
- Number of animals:
- not applicable: see "any other information on materials and methods"
- Details on study design:
- not applicable: see "any other information on materials and methods"
Results and discussion
In vivo
- Irritant / corrosive response data:
- Under the experimental conditions, the test item was not irritating to skin.
Any other information on results incl. tables
Table 1: Absorption Values negative control, test item and positive control (Optical Density at 570 nm)
Designation |
Measurement |
Negative Control |
Molybdenum nickel tetraoxide |
Positive Control |
Tissue 1 |
1 |
1.579 |
1.813 |
0.210 |
2 |
1.788 |
1.817 |
0.218 |
|
Tissue 2 |
1 |
1.769 |
1.970 |
0.184 |
2 |
1.596 |
1.972 |
0.187 |
|
Tissue 3 |
1 |
1.724 |
2.026 |
0.222 |
2 |
1.203 |
1.773 |
0.234 |
Table 2: Mean absorption Values (subtracting the blank)
Designation |
Negative Control |
Molybdenum nickel tetraoxide |
Positive Control |
Mean – blank (Tissue 1) |
1.614 |
1.745 |
0.144 |
Tissue 2 |
1.613 |
1.901 |
0.116 |
Tissue 3 |
1.394 |
1.830 |
0.158 |
Mean of three Tissues |
1.540 |
1.825 |
0.139 |
Relative Standard Deviation of the three tissues |
8.2% |
4.3% |
15.4% |
Table 3: % Formazan Production
Designation |
Molybdenum nickel tetraoxide |
Positive Control |
% Formazan production (Tissue 1) |
113.3% |
9.4% |
% Formazan production (Tissue 2) |
123.4% |
7.5% |
% Formazan production (Tissue 3) |
118.8% |
10.3% |
% Formazan production Mean |
118.5% |
9.0% |
Table 4: Validity
Criterion |
Demanded |
Found |
OD of negative control |
between 1.0 and 2.5 |
1.540 |
% Formazan production of positive control |
<20% of negative control |
9.0% |
Variation within replicates (RSD) |
<18% |
8.2% (negative control) 15.4% (positive control) 4.3% (test item) |
For the test item 118.5% Formazan production (mean of three tissues) were calculated in comparison to the negative control.
This value is well above the threshold for irritancy of 50%.
For the positive control 9.0% Formazan production (mean of three tissues) were calculated in comparison to the negative control.
Values for negative control and for positive control were within the range of historical data of the test facility. The test item Molybdenum nickel tetraoxide is considered not irritant using this in vitro test with a skin model. Therefore, prediction in- vivo is "not irritant" following the proposals of the guideline.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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