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Diss Factsheets
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EC number: 231-977-3 | CAS number: 7783-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Objective measures of ocular irritation as a consequence of hydrogen sulfide exposure
- Author:
- Lefebvre M, Yee D, Fritz D and Prior MG
- Year:
- 1 991
- Bibliographic source:
- Vet. Human. Toxicol. 33, 564-566
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The exfoliative eye cytology technique was evaluated as a means of measuring the ocular irritation resulting from H2S exposure.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
- Molecular formula:
- H2S
- IUPAC Name:
- hydrogen sulfide
- Details on test material:
- Source: Matheson Gas Products Ltd (Edmonton, AB, Canada)
Constituent 1
Test animals / tissue source
- Species:
- rat
- Strain:
- Fischer 344
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Canada Inc (Point Claire, PQ, Canada)
- Age at study initiation: 10-w old
- Weight at study initiation: no data
- Housing: separately in suspended wire cages
- Diet (e.g. ad libitum): Wayne Certified Rodent Blox
- Water : ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24.5 ± 0.1
- Humidity (%): 33.0 ± 0.7
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 400 or 1500 ppm
- Duration of treatment / exposure:
- 4 min or 4 hours
- Number of animals or in vitro replicates:
- not stated
- Details on study design:
- Rats were exposed to either 0 or 400 ppm (560 mg m-3) H2S for 4 h or 1500 ppm (2100 mg m-3 H)2S for approximately 4 min in a 118 L sliding drawer type wholebody chamber. Hydrogen sulphide exposures were completed over 3 days at chamber concentrations (mean ± SE) of 523.7 ± 2.0, 534.8 ± 1.3, and 2147.9 ± 14.1 mg m-3 H2S, respectively.
Immediately after exposure, the eyes were washed with 0.4 ml of saline and the lavage fluid collected for exfoliative cytology.
Results and discussion
In vivo
Results
- Remarks on result:
- other: The number of exfoliated cells was increased in animals exposed to hydrogen sulfide (44.3 cells/μL at 560 mg/m3; 35 cells/μL at 2100 mg/m3) compared to control (18-22 cells/μL).
- Irritant / corrosive response data:
- The number of exfoliated cells was increased in animals exposed to hydrogen sulfide (44.3 cells/μL at 560 mg/m3; 35 cells/μL at 2100 mg/m3) compared to control (18-22 cells/μL). Exposure to hydrogen sulfide also increased the proportion of conjunctival to corneal epithelial cells recovered compared to controls.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Male Fischer 344 rats (number per group not stated) were exposed to 0, or 400 ppm hydrogen sulfide for 4 hours or 1500 ppm hydrogen sulfide for 4 minutes. Immediately after exposure, the eyes were washed with 0.4 ml of saline and the lavage fluid collected for exfoliative cytology. Exposure to hydrogen sulfide increased the number of exfoliated cells and the proportion of conjunctival to corneal epithelial cells recovered compared to controls.
This can be seen as a consequnece of an irritation to the eye. - Executive summary:
Male Fischer 344 rats (number per group not stated) were exposed to 0, or 400 ppm hydrogen sulfide for 4 hours or 1500 ppm hydrogen sulfide for 4 minutes. Immediately after exposure, the eyes were washed with 0.4 ml of saline and the lavage fluid collected for exfoliative cytology. The number of exfoliated cells was increased in animals exposed to hydrogen sulfide (44 cells/μL at 560 mg/m3; 35 cells/μL at 2100 mg/m3) compared to control (18 -22 cells/μL). Exposure to hydrogen sulfide also increased the proportion of conjunctival to corneal epithelial cells recovered compared to controls.
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