Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-251-1 | CAS number: 136-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
No acute toxicity studies with zinc bis(2-ethylhexanoate) are available. In the assessment of toxicity of zinc bis(2-ethylhexanoate), read-across to the assessment entities zinc and 2-ethylhexanoic acid is applied since the ions of zinc bis(2-ethylhexanoate) determine its toxicity in biological compartments.
Signs of acute oral or acute dermal toxicity are not expected for zinc bis(2-ethylhexanoate), since its two moieties zinc and 2-ethylhexanoic acid have not shown signs of acute oral or acute dermal toxicity in experimental testing (both LD50 > 2000mg/kg).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute toxicity
Existing data on the acute toxicity of the two moieties of bis(2-ethylhexanoate) are detailed below.
Zinc
Acute oral toxicity
- With LD50 values consistently exceeding 2,000 mg/kg bw, zinc oxide (LD50 ranges between 5,000 and 15,000mg/kg bw), shows very low level of acute oral toxicity.
Acute inhalation toxicity
- Key study carried out according to OECD guideline no 403 indicating for micro zinc oxide LC50 > 5.7 mg/L/4hrs
Acute dermal toxicity
- There are no available data on which to evaluate acute dermal toxicity for ZnO micromaterial. However, acute dermal toxicity can be considered to be low taking into account the poor percutaneous absorption of zinc oxide or the zinc cation.
2-ethylhexanoate
Acute oral toxicity
In an acute oral toxicity study 4 rats/sex/dose were dosed with 90, 722, 1445 or 2890 mg/kg bw. No mortality was observed in the 90, 722 and 1445 mg/kg bw dose groups. The test material caused mortality in rats administered a dose of 2890 mg/kg bw (4/4), and transitory weakness at lower doses in a dose-dependent manner. The LD50 was calculated to 2043 mg/kg bw. In another acute oral toxicity study 5 rats/sex/dose have been administered 0.2, 1.6, 3.2 and 4.0 ml 2-ethylhexanoic acid/ kg bw. No substance related clinical signs nor mortality was observed at 0.2 and 1.6 ml/kg. However, 1/10 animals died. After administration of 3.2 ml/kg and 4 ml/kg apathy dyspnoea abdominal position and re crusted eyes and snouts were observed. Mortality in these dose groups was 3/10, 5/10, respectively. LD 50 was estimated to be 4 mL/kg bw, being equivalent to 3640 mg/kg bw (density 0.91 g/ml). This result is supported by another study which however was poorly documented no signs of a toxicity response. It is concluded that the LD50 is greater than 3640 mg/kg. This result is supported by another study which however was poorly documented.
Acute inhalation toxicity
No mortality in 12 rats (6 m;6f) was observed after 8 h exposure to saturated 2-ethylhexanoic acid vapour in an inhalation hazard test comparable to OECD 403 Annex 1. Maximal achievable concentration in this test system was 0.11 mg/L (Nominal concentration). No acute toxicity has to be expected from 2-ethylhexanoic acid vapour at normal conditions of use. The test demonstrates that vapour inhalation is not the relevant rout for exposure concerning acute toxicity.
Acute dermal toxicity
Dermal toxicity of 2-ethylhexanoic acid was tested in an OECD 402 guideline study. Five Wistar rats/sex/dose have been exposed dermally (semi-occlusive to a limit dose of 2000 mg/kg bw 2‑ethylhexanoic acid. No mortality and no clinical symptoms beside eschar formation have been observed. LD50 dermal therefore is > 2000 mg/kg bw.
Table: Summary of acute toxicity data of zinc bis(2-ethylhexanoate) and the assessment entities.
|
(slightly soluble) zinc substances |
2-ethylhexanoic acid (CAS# 149-57-5) |
Zinc bis(2-ethylhexanoate) (CAS# 136-53-8) |
Acute oral toxicity |
LD50(rat)>2,000 mg/kg bw |
LD50(rat)= 2,043 mg/kg bw |
LD50>2,000 mg/kg bw (calculated) |
Acute inhalation toxicity |
LD50>5.7mg/L |
LD0= 0.11 mg/L air (nominal) |
waived, since the substance is used and placed on the market in a non-inhalable form |
Acute dermal toxicity |
LD50> 2,000 mg/kg bw |
LD50> 2,000 mg/kg bw |
LD50>2,000 mg/kg bw (calculated) |
Zinc bis(2-ethylhexanoate)
Signs of acute oral or acute dermal toxicity are not expected for zinc bis(2-ethylhexanoate), since its two moieties zinc and 2-ethylhexanoic acid have not shown signs of acute oral or acute dermal toxicity. Under the assumption that the two moieties of zinc bis(2-ethylhexanoate) show their toxicological profile individually upon dissolution, the acute oral and dermal (systemic) toxicity of zinc bis(2-ethylhexanoate) can be calculated using the equation given in regulation (EC) 1272/2008, Annex I, Section 3.1.3.6.1.
The calculated oral and dermal LD50 for zinc bis(2-ethylhexanoate) is > 2000mg/kg, hence the substance is not to be classified according to regulation (EC) 1272/2008 for acute oral and dermal toxicity as well as for specific target organ toxicity, single exposure (STOT SE). Further testing is not required. For further information on the toxicity of the the two moieties of zinc bis(2-ethylhexanoate), please refer to the relevant assesment entity sections in the IUCLID and CSR.
Justification for classification or non-classification
The calculated oral and dermal LD50 for zinc bis(2-ethylhexanoate) is > 2000 mg/kg, hence the substance is not to be classified according to Regulation (EC) 1272/2008 for acute oral and dermal toxicity as well as for specific target organ toxicity, single exposure (STOT SE).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.