Registration Dossier

Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
according to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
test conditions (temperature, humidity) due to laboratory environment; 1 meaurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). 77.6 g (443.4 cm3) test material are used for the measurement, dosing rate: 7.8 g/min

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide
EC Number:
229-440-3
EC Name:
3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide
Cas Number:
6535-46-2
Molecular formula:
C24H16Cl3N3O2
IUPAC Name:
3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide
Test material form:
solid: nanoform, no surface treatment

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
314 652.81 other: 1/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
46 069.92 other: N/cm3
Remarks on result:
other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

measurement duration: 10 min

temperature: 21°C, rel. air humidity 45 %

The cleaned, almost particle-free air had a total particle count of 6 particles/cm3 in the range of 10 nm - 417 nm, the nanoscale fraction (10 - 100 nm) contained 4 particles/cm3.

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]

Mean [nm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

10 - 100

72.57

46069.92

314652.81

524.42

100 - 417

153.49

92577.94

632297.80

1053.83

10 - 417

126.60

138647.86

946950.61

1578.25

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]

Mean [µm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

0.3 - 10

5.48

360.70

2463.53

4.11

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Copntinuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 138647.86 particles per cm3 (in the nanoscale (10 - 100 m) 46069.92 particles per cm3) corresponding to a dustiness index of 946950.61 particles per mg (in the nanoscale (10 - 100 nm) 314652.81 particles per mg). The mean size of the nanoparticles was 126.60 nm, the mean size of particles in the range 10 - 417 nm was 72.57.

The OPS (0.3 - 10 µm) counted 360.70 particles per cm3 corresponding to a dustiness index of 2463.53 particles per mg. The mean size of the particles was 5.48 µm.