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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Expert Statement: Investigation of the reaction of sodium polysulfide solution with diluted hydrochloric acid. No standard guideline followed and the study was not performed accoridng to GLP.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: see conclusion
The reaction PSL / diluted hydrochloric acid clearly prove the decomposition reaction with formation of elementary sulfur and hydrogen sulfide according to the reaction scheme in the literature. (Hollemann Wiberg)
Executive summary:

The task of the intended investigations consisted in studying the reaction of diluted hydrochloric acid with aqueous sodium polysulfide solution (PSL) to simulate a poisoning process inside a human body. It should be confirmed that the reaction comprises a decomposition into hydrogen sulfide and elementary sulfur. The rate of the reaction and the quantity of the decomposition products should be evaluated.

The lab investigations of the reaction PSL / diluted hydrochloric acid clearly prove the decomposition reaction with formation of elementary sulfur and hydrogen sulfide according to the reaction scheme in the literature. (Hollemann Wiberg)

The following facts support this thesis:

- elementary sulfur has been identified and determined quantitatively

- hydrogen sulfide has been determined quantitatively.

- short time after the reaction after rinsing the reaction mixture with nitrogen the mixture is free of sulfid or polysulfide ions. The disappearance of all sulfid and polysulfide ions out of the reaction mixture can only be explained by the formation of hydrogen sulfide. It is flushed out of the system. The intermediate sulfanes aren`t gases and subsequently not volatile. They would give the colour reaction with Pb-acetate in the reaction mixture and would not appear in the wash bottles with NaOH because of their low volatility after rinsing with nitrogen.

The reaction rate of the decomposition reaction is high. According to the visual course of the reaction (spontaneous servere gas emission, immediate precipitation of sulfur) the reaction runs within seconds. And the reaction runs completely. Already a few minutes after rinsing the hydrogen sulfide out of the reaction mixture no sulfide and polysulfide ions can be detected.