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EC number: 233-296-7 | CAS number: 10108-64-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jan, 1975 to Nov, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reliable with restriction. well documented. Not according to GLP nor to specific test guideline
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Routine patch testing with cadmium chloride
- Author:
- Wahlberg JE
- Year:
- 1 977
- Bibliographic source:
- Cont. Dermat. 3(6):293-296
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Human patch test
- GLP compliance:
- no
Test material
- Reference substance name:
- Cadmium chloride
- EC Number:
- 233-296-7
- EC Name:
- Cadmium chloride
- Cas Number:
- 10108-64-2
- Molecular formula:
- CdCl2
- IUPAC Name:
- cadmium(2+) dichloride
- Details on test material:
- CdCl2
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 1502
- Sex: M + F
- Age: 24-68 y
- Known diseases: Eczema - Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- 2% CdCl2 solution, serial dilutions: 1%-0.5%-0.06%
- Examinations:
- skin allergy
- Medical treatment:
- not applicable
Results and discussion
- Clinical signs:
- - 25 of 1502 eczema patients showed skin reactions (1.7%)
- Results of examinations:
- skin irritation
- Effectivity of medical treatment:
- not applicable
- Outcome of incidence:
- - 25 of 1502 eczema patients showed skin reactions (1.7 %) with 2% CdCl2
- At serial dilution test: only one patient reacted to 1% CdCl2; all the other dilutions applied gave negative reactions
- No certain case of contact allergy to CdCl2 has been revealed
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Conclusions:
- No conclusive case of contact allergy to cadmium chloride has been found in this study.
- Executive summary:
During a 22-month period, 2.0 % cadmium chloride in distilled water was included in routine patch test series. Twenty-five of 1502 eczema patients showed reactions (1.7 %), but none had any relevant history. At serial dilution test only one patient reacted to 1.0% cadmium; all the other dilutions applied gave negative reactions. Analysis by atomic absorption spectrophotometry of the cadmium chloride used for patch testing showed that it contained less than 1 µg/g of chromium, copper, cobalt and nickel. The conclusion is that no certain case of contact allergy to cadmium chloride has been revealed. An experimental study using the guinea pig maximization test is in progress.
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