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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
experimental study
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook.

Data source

Reference Type:
review article or handbook
Pschyrembel Klinisches Wörterbuch
Pschyrembel, W.
Bibliographic source:
De Gruyter Publishing, 263rd ed., 2012

Materials and methods

Type of study / information:
Clinical dictionary
Test guideline
no guideline followed
Principles of method if other than guideline:
not applicable
GLP compliance:

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Not applicable, general physiological information

Results and discussion

Any other information on results incl. tables

Bile salts:

Components of bile synthesised in the liver from cholesterol. They can be subdivided into primary bile salts cholate and chenodeoxycholate and the secondary bile salts deoxycholate and lithocholate. They can be conjugated to glycine or taurine forming glycocholate and taurocholate, respectively, and are recycled 6-8 times per day in the enterohepatic cycle. Functions: They aid in the emulsification of triglycerides, activate digestive enzymes by shift of the pH-value and have an influence on the peristalsis of small intestines and colon (inhibition and stimulation, respectively).


Lipoprotein particles of low density with a high level of lipids (98-99.5%; remaining fraction: apolipoproteins) which are synthesised in the gut mucosa. They are transported into the blood via the lymphatic system (thoracic duct) and carry triglycerides absorbed from foods. The triglycerides in the chylomicrons are degraded by endothelial lipoprotein lipase in the blood vessels, leading to formation of chylomicron remnants, which are precursors for VLDL and HDL in the liver.

Thoracic duct:

The thoracic duct drains the lymph of the complete lower and left upper parts of the body into the bloodstream at the left venous angle.

Applicant's summary and conclusion