Registration Dossier
Registration Dossier
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EC number: 931-801-1 | CAS number: -
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of fatty acid amides in human plasma.
- Author:
- Arafat, E.S. et al.
- Year:
- 1 989
- Bibliographic source:
- Life Science, Vol 45: 1679-1687 .
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- other: human fatty acid amide plasma levels
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Identification of fatty acid amides in human plasma.
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Not applicable, determination of endogenous oleamide levels.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects: 16
- Sex: females - Ethical approval:
- not specified
- Route of exposure:
- other: not applicable
- Reason of exposure:
- other: Not applicable as no exposure was performed. Naturally occurring oleamide was determined in human plasma.
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- No clinical signs reported.
Any other information on results incl. tables
Naturally occurring oleamide was reported to be one of five primary fatty acids amine present in human plasma; endogenous levels up to 31.7 µg/mL have been reported. Clearly, the C18:1 amide dominates the plasma fatty acid amides content.
However, it should be noted that this value represents a case observation in a single person, representative for 10 of the 16 tested individuals, but without the manifestation of effects; in the other 6 individuals investigated in the same study oleamide plasma levels were much lower or not detectable.
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