Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 931-801-1 | CAS number: -
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of fatty acid amides in human plasma.
- Author:
- Arafat, E.S. et al.
- Year:
- 1 989
- Bibliographic source:
- Life Science, Vol 45: 1679-1687 .
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- other: human fatty acid amide plasma levels
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Identification of fatty acid amides in human plasma.
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Not applicable, determination of endogenous oleamide levels.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects: 16
- Sex: females - Ethical approval:
- not specified
- Route of exposure:
- other: not applicable
- Reason of exposure:
- other: Not applicable as no exposure was performed. Naturally occurring oleamide was determined in human plasma.
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- No clinical signs reported.
Any other information on results incl. tables
Naturally occurring oleamide was reported to be one of five primary fatty acids amine present in human plasma; endogenous levels up to 31.7 µg/mL have been reported. Clearly, the C18:1 amide dominates the plasma fatty acid amides content.
However, it should be noted that this value represents a case observation in a single person, representative for 10 of the 16 tested individuals, but without the manifestation of effects; in the other 6 individuals investigated in the same study oleamide plasma levels were much lower or not detectable.
Applicant's summary and conclusion
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