Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

One GLP study was available for acute oral and acute dermal toxicity, respectively. In both acute studies the LD50 was > 2000 mg/kg bw. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

The harmonized data infers that 4,4 -methylenebis(2 -chloroaniline) is classified for R22, however latest studies performed by Japanese laboratories have shown that this classification is not justified.

Justification for classification or non-classification

Based on the results of the acute toxicity studies, the substance does not need to be classified according to the Dangerous Substance Directive 67/548/EC and CLP Regulation (EC) 1272/2008.

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