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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
other: publication
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The data concern a literature study; human neonatal foreskin is isolated and placed in a diffusing chamber. The integrity of the cell layers is only checked histologically; the experiment contains no sufficient positive control on integrity of the cell layer.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1983
Report date:
1982

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Freshly human neonatal foreskin was prepared to form a layer between two compartments. *MOCA was added to the upper compartment, samples were taken at t = 1, 2, 3, and 4 hours.
GLP compliance:
not specified

Test material

Constituent 1
Radiolabelling:
yes
Remarks:
14C

Test animals

Species:
human
Strain:
other: neonatal foreskin

Administration / exposure

Duration of exposure:
t = 1, 2, 3, and 4 hr.
Details on in vitro test system (if applicable):
SKIN PREPARATION
- Source of skin: neonatal foreskin
- Membrane integrity check: solely histologically

Results and discussion

Applicant's summary and conclusion

Conclusions:
The authors suggest that *MOCA is rapidly absorbed through the human foreskin. Since, the integrity of the cell layer is not sufficiently controlled, the data may be considered as doubtful.