Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-695-3 | CAS number: 124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-06-06 to 1989-06-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD guideline 405 and in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Octadecylamine
- EC Number:
- 204-695-3
- EC Name:
- Octadecylamine
- Cas Number:
- 124-30-1
- Molecular formula:
- C18H39N
- IUPAC Name:
- octadecan-1-amine
- Test material form:
- other: wax
- Details on test material:
- Chemical name: Octadecylamine
EC no.: 204-690-6
To the best of knowledge, the sample used is representative to the boundary composition shared and agreed by each registrant.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Kastengrund, conventional breed
- Weight at study initiation: 2.29 kg
- Age at study initiation: ca. 3 - 5 months
- Housing: fully air-conditioned rooms, cages on their own
- Diet (e.g. ad libitum): Altromin 2113 (supplied by Altromin GmbH Lage/Lippe)ad libitum and hey (ca. 15 g daily)
- Water (e.g. ad libitum): deionized, chlorinated water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +-3°C
- Humidity (%): 50 +-20 %
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL Genamin 18 R 100 D - Duration of treatment / exposure:
- 24 hrs
- Observation period (in vivo):
- 1, 24, 48, 72 hrs, 7 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with warm (37°C) physiological saline solution
- Time after start of exposure: 24 hrs
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein
0.01 % fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24h / 48h / 72h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- corneal vascularisation after 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24h / 48h / 72h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24h / 48h / 72h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24h / 48h / 72h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Irritating [Xi] - R41- Risk of serious damage to eyes
- Executive summary:
In an OECD TG 405 study, 0.1 ml of the test material Genamin 18 R 100 D (octadecylamine), a whitish waxy solid (purity approximately 100%), was applied to the eye of one New Zealand White rabbit. 24 hours after treatment, the eye was washed with 0.9% tepid NaCl solution. From 1 hour on, the conjunctiva showed red beefy discoloration and pronounced chemosis. Iris and cornea showed lesions. Additionally, a clear colourless to whitish-slimy discharge was noted. Due to progressed vascularisation of the eye, the study was terminated after 7 days. Mean Draize scores for conjunctiva redness and chemosis at 24, 48 and 72 hours were 3.0, 3.0 and 3.0. Mean scores for iris were 1.0, 1.0 and 1.0 and for cornea opacity were 2.0, 2.0 and 2.0 (same time points)
According to the results of the study the test substance Genamin 18 R 100 D has to be regarded as irritating (Xi – R41- Risk of serious damage to eyes) in compliance with the criteria laid down in 83/467/EWG.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.