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EC number: 233-071-3 | CAS number: 10028-18-9
E= eutanized via CO2 inhalation after weighing on day 14
DEVIATION FROM PROTOCOL:
The protocol requires that all decedents will be wheight immediately, or as soon as possible after death. Due to a technician error, the terminal bodywheights for animal n° 3106 was not recorded at the time of death. This deviation had no material impact on the results of study.
An acute oral toxicity test (up and down Procedure) was conduced with rats to determine the potential for nickel(II) fluoride tetrahydrate to procedure toxicity from a single dose via the oral route. Under the conditions of this study, the acute oral LD50 of the test substance is estimated to be 310.2 mg/kg of body weight in female rats with an approximate 95% confidence interval of 175 mg/kg (lower) to 550 mg/kg (upper).
A main test was conducted using a default starting dose level of 175 mg/kg, which was administered to one healty female rat oral gavage. Following the up and down procedure, five additional animals were dosed at levels of 175 or 550 mg/kg. Females were selected for the test because they are frequently more sensitive to the toxicity of test compounds than males. All animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days after dosing or until death occured. Body weights were recorded prior to administration and again on days 7 and 14 (termination) following dosing or after death. Necropsies were performed on all animals.
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