Registration Dossier
Registration Dossier
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EC number: 203-825-6 | CAS number: 111-01-3
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,6,10,15,19,23-hexamethyltetracosane
- EC Number:
- 203-825-6
- EC Name:
- 2,6,10,15,19,23-hexamethyltetracosane
- Cas Number:
- 111-01-3
- Molecular formula:
- C30H62
- IUPAC Name:
- 2,6,10,15,19,23-hexamethyltetracosane
- Test material form:
- other: liquid
Constituent 1
Study design
HPLC method
- Details on study design: HPLC method:
- Preparation of sample solution: Test item (0.1106 g) was diluted to 10 mL with tetrahydrofuran.
Preparation of dead time solution: The dead time was determined by measuring the retention time of formamide (purity : 99.94 %, 664 mg/L solution in mobile phase).
As the test item had a high affinity for the stationary phase of the column, the mobile phase was adjusted to 100% tetrahydrofuran after the retention time of DDT in order to elute the highly retained test item.
Testing was carried out at approximately neutral pH with the test item in a non-ionized form.
As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for each solution was consistent, the HPLC method was considered valid for the estimation of adsorption coefficient. Based on the chromatographic data, the test item was considered to be stable during the test procedure.
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- >= 5.63
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item has been determined to be greater than 4.27 x 105, log10 Koc greater than 5.63. This value indicates that the test item will be environmentally immobile.
- Executive summary:
The adsorption coefficient of Squalane (CAS 111-01-3) has been determined to be greater than 4.27 x 105, log10 Koc greater than 5.63, using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
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