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EC number: 500-041-9 | CAS number: 25723-16-4 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Assessment of the toxicokinetic behaviour as can be derived from the available information
- Adequacy of study:
- weight of evidence
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
- Principles of method if other than guideline:
- Review of reports summarised in the dataset
Test material
- Reference substance name:
- Propylidynetrimethanol, propoxylated
- EC Number:
- 500-041-9
- EC Name:
- Propylidynetrimethanol, propoxylated
- Cas Number:
- 25723-16-4
- Molecular formula:
- C3H5(CH2OR)3 R= (C2H3(CH3)O)nH sum of n: >1 - <6.5 mol PO
- IUPAC Name:
- Propylidynetrimethanol, propoxylated
- Reference substance name:
- not applicable
- Molecular formula:
- >= C102H156N30O18
- IUPAC Name:
- not applicable
Constituent 1
Constituent 2
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Because of the vapour pressure and water solubility of the commercial material, some of the lower molecular weight components of the substance
are likely to be absorbed via the lung if inhaled. No useful prediction concerning oral absorption can be made on the basis of the logP of the commercial material as there should be a range of values, one for each of the components. Based on read across from pentaerythritol and nitrilotriethanol, it is likely that propylidyne trimethanol is absorbed when administered orally. Propane-1,2-diol and [(methylethylene)bis(oxy)]- dipropanol (and probably, oxydipropanol ) are also absorbed, probably by passive diffusion, when administered orally. Thus it is possible that the smaller polyols may be absorbed. Given the measured logP and water solubility, dermal absorption is likely. - Details on distribution in tissues:
- Given the logP values, it is likely that any absorbed oligomers of propoxylated propylidyne trimethanol will be widely distributed in body water. If not
metabolised, it is unlikely that they will accumulate in tissues.
- Details on excretion:
- In the event that higher molecular weight material is absorbed, it is likely to be excreted in bile. Lower molecular weight unmetabolised oligomer is likely to be excreted in urine. In rat the molecular weight threshold for biliary excretion is around 350, in human it is about 500 (Illing, 1989). The material most likely to be absorbed is likely to be hydrolysed and the products appear in urine, except when the end point of metabolism is carbon dioxide. Carbon dioxide will be exhaled.
Metabolite characterisation studies
- Details on metabolites:
- Based on information from the propane-1,2-diol trimer [(methylethylene)bis (oxy)]dipropanol, if absorbed, the propane-1,2-diol moiety of the propoxylated propylidyne trimethanol could be further conjugated (with glucuronic acid or sulphate) or stepwise hydrolysed. Propane-1,2-diol is also further metabolised, entering intermediary metabolism via lactic acid/pyruvic acid, and eventually being eliminated as carbon dioxide. Based on read across from pentaerythritol and nitrilotriethanol, it is likely that any propylidyne trimethanol released will be excreted unchanged in the urine.
Any other information on results incl. tables
There are no experimental studies on the toxicokinetics of propoxylated propylidyne trimethanol. The toxicokinetics of propoxylated propylidyne trimethanol is inferred from the core substance and propane-1,2- diol, oxydipropanol and [(methylethylene)bis(oxy)]dipropanol. Propylidyne trimethanol has three free hydroxy groups, thus NLP polyols are likely to consist predominantly of chains of between one and two repeating units, with some chains containing three repeating units.
Applicant's summary and conclusion
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