Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-041-9 | CAS number: 25723-16-4 1 - 6.5 moles propoxylated
Endpoint summary
Administrative data
Description of key information
Additional information
The 96 hr LC50 to fish were reported as > 100 mg/l (nominal)(EU Method C1 , Danio rerio).
The 48 hr EC50 to aquatic invertebrates were reported as >100 mg/L(nominal) (Daphnia magna).
The 21d-NOEC to aquatic invertebrates is ≥ 8.5 mg/L (nominal) for all endpoints (nominal)(Daphnia magna).
72 hr ECr50 (Desmodesmus subspicatus) > = 100 mg/l.
72 hr NOEC (Desmodesmus subspicatus) > = 100 mg/l.
72 hr ECr50 (Pseudokirchnerella subcapitata) = 106 mg/l.
72 hr NOEC (Pseudokirchnerella subcapitata) = 31 mg/l.
3 hr (domestic sludge respiration rate inhibition) EC10 is >10,000 mgl/l . No inhibition of respiration was observed.
Read-across statement
No-Longer-Polymer (NLP) polyether polyols are produced by the reaction of various starter molecules with propylene oxide and/or ethylene oxide. These substances exhibit a remarkable uniformity in the physical/chemical properties which influence their fate and distribution in the environment. All NLP polyols have a full acute aquatic ecotoxicity dataset and do not exhibit acute toxicity below 100 mg/L. However, differentiation in chronic invertebrate toxicity is apparent and is based on the alcohol- or amino- starter molecules used to prepare these NLP polyols. A sub-grouping based on (i) aliphatic alcohol and amine NLP polyols, (ii) EDA- (ethylenediamine) based amino NLP polyols and (iii) o-TDA- (orthodiaminotoluene) based aromatic NLP polyols is justified (ISOPA, 2010) and toxicity is expected to be similar between substances within each of these categories. It is considered appropriate to use ‘read-across’ of data of structural analogues within each sub-grouping to fill data gaps for chronic invertebrate toxicity and derive PNECs for endpoints based on these sub-groupings.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
