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EC number: 203-906-6 | CAS number: 111-77-3
No irritation response observed in range finding tests therefore the maximum concentrations were used for the main study. There was no effect on body weight. Due to strong irritation reactions of the skin after intradermal injection with FCA (both with and without test substance), 10% sodium dodecylsuphate was not applied at day 6. After removal of the patches on day 10, severe erythema dand oedema, indurated, scabbed and encrusted skin as well as necrosis was observed at the sites previously treated with FCA. Application sites treated with test substance or isotonic saline alone showed no signs of irritation.
In a guinea pig maximisation study conducted to current guidelines, 2 -(2 -methoxyethoxy)ethanol showed no signs of a causing a sensitisation response. Intradermal induction was performed using 5% substance in isotonic saline and dermal induction and challenge exposures used undiluted material. There was no evidence of any irritant response either during the range finder studies.
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