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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Docosan-1-ol
EC Number:
211-546-6
EC Name:
Docosan-1-ol
Cas Number:
661-19-8
Molecular formula:
C22H46O
IUPAC Name:
docosan-1-ol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.8% hydroxypropyl-methylcellulose gel
Doses:
8250 and 10000 mg/kg
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw

Any other information on results incl. tables

MORTALITY: All animals survived the 14 day observation period.

CLINICAL SIGNS: No clinical signs of toxicity. There was no adverse  effect on food intake or bodyweight gain.

NECROPSY FINDINGS: Unremarkable.

POTENTIAL TARGET ORGANS: None identified.

SEX-SPECIFIC DIFFERENCES: None

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The rat oral LD50 for Nacol 22 RD is >10g/kg. At this dose level there was no evidence of toxicity in any of the parameters monitored.