Registration Dossier
Registration Dossier
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EC number: 204-809-1 | CAS number: 126-86-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- 5 male rats (average weight 176 grams) and 5 female rats (average weight 211 grams) were placed in a 306 liter chamber. The Surfynol 104 was prepared as a 5% aqueous solution. An air flow of five liters per minute was introduced into the chamber. The test solution was aerosolized to provide a concentration of greater than 20 mg of mist per liter of chamber air over the one-hour period. The test atmosphere was not analyzed. The animals were observed daily for 14 days.
- GLP compliance:
- no
- Test type:
- other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association
Test material
- Reference substance name:
- 2,4,7,9-tetramethyldec-5-yne-4,7-diol
- EC Number:
- 204-809-1
- EC Name:
- 2,4,7,9-tetramethyldec-5-yne-4,7-diol
- Cas Number:
- 126-86-3
- Molecular formula:
- C14 H26 O2
- IUPAC Name:
- 2,4,7,9-tetramethyldec-5-yne-4,7-diol
- Details on test material:
- 5 % of aqueous solution
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 20 mg of mist per liter
- No. of animals per sex per dose:
- 5 male and
5 female - Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Any other information on results incl. tables
Ocular and nasal irritation as well as a reduction in spontaneous activity were noted in all animals at the end of the one-hour exposure period. These symptoms disappeared within three hours.
All rats survived the one-hour exposure and the 14 -day observation period (post exposure).
All animals maintained a normal appearance and gained weight over the observation period. No evidence of gross lesions was found in the animals autopsied. Body weight data are presented in the following summary:
Sex Initial Final Change
M 176 g 288 g + 112 g
F 211 g 239 g + 28 g
Material Sex Initial Final Change
Surfynol 104 M 176 g 288 g + 112 g
- " - F 211 g 239 g + 28 g
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based upon the results of this study, it was concluded that the Surfynol 104 sample submitted was not a toxic substance by inhalation according to specifications for such substances set forth by the Manufacturing Chemist´s Association, Inc.:
" ... a toxic substance falls within the following category: "a substance that has a median lethal concentration (LC50) in air of more than ..... 2 milligrams per liter but not more than 20 milligrams per liter of mist ..... when administrered by continuous inhalation for one hour or less to albino rats weighing between 200 grams and 300 grams each ... " - Executive summary:
Ocular and nasal irritation as well as a reduction in spontaneous activity were noted in all animals at the end of the one-hour exposure period. These symptoms disappeared within three hours.
All rats survived the one-hour exposure and the 14 -day observation period (post exposure).
All animals maintained a normal appearance and gained weight over the observation period. No evidence of gross lesions was found in the animals autopsied.
Material Sex Initial Final Change
Surfynol 104 M 176 g 288 g + 112 g
- " - F 211 g 239 g + 28 g
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