Docosan-1-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

result reporting is limited

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data: List VII.

Author:

Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 30(5): 470-476

Materials and methods

Principles of method if other than guideline:

Method: other: Smyth et al, 1962

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Eicosanol, mixed isomers

IUPAC Name:

Eicosanol, mixed isomers

Test material form:

not specified

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

- Source: no data
- Weight at study initiation: 2.5 -3.5 kg
- Group size: 4
- Controls: no

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

- Area covered: entire trunk

No. of animals per sex per dose:

4

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 20 mL/kg bw

Based on:

test mat.

Any other information on results incl. tables

Results were not reported in detail. The LD50 was >20 ml/kg. (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). No further 

details available.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of >20 ml/kg is reported in a relaible study conducted according to appropriate protocol. The study is a read across from 1-icosanol (CAS 629-96-9).

Executive summary:

In an acute dermal toxicity study, the test material (icosan-1 -ol) was applied onto rabbit skin and kept in contact to the skin for 4 hours under occlusive dressing. There is lack of detail on the materials and methods used, as well as results, however the study reports an LD50 value of > 20 ml/kg (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). The study meets generally accepted scientific principles, acceptable for assessment. Study considered valid although result reporting is limited. The study is a read across from icosan-1-ol (CAS 629-96-9).