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EC number: 211-546-6 | CAS number: 661-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- result reporting is limited
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30(5): 470-476
Materials and methods
- Principles of method if other than guideline:
- Method: other: Smyth et al, 1962
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Eicosanol, mixed isomers
- IUPAC Name:
- Eicosanol, mixed isomers
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Source: no data
- Weight at study initiation: 2.5 -3.5 kg
- Group size: 4
- Controls: no
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - Area covered: entire trunk
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Results were not reported in detail. The LD50 was >20 ml/kg. (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). No further
details available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of >20 ml/kg is reported in a relaible study conducted according to appropriate protocol. The study is a read across from 1-icosanol (CAS 629-96-9).
- Executive summary:
In an acute dermal toxicity study, the test material (icosan-1 -ol) was applied onto rabbit skin and kept in contact to the skin for 4 hours under occlusive dressing. There is lack of detail on the materials and methods used, as well as results, however the study reports an LD50 value of > 20 ml/kg (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). The study meets generally accepted scientific principles, acceptable for assessment. Study considered valid although result reporting is limited. The study is a read across from icosan-1-ol (CAS 629-96-9).
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