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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
result reporting is limited

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30(5): 470-476

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth et al, 1962
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Eicosanol, mixed isomers
IUPAC Name:
Eicosanol, mixed isomers
Test material form:
not specified

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
- Source: no data
- Weight at study initiation: 2.5 -3.5 kg
- Group size: 4
- Controls: no



Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
- Area covered: entire trunk

No. of animals per sex per dose:
4

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw
Based on:
test mat.

Any other information on results incl. tables

Results were not reported in detail. The LD50 was >20 ml/kg. (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). No further 

details available.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of >20 ml/kg is reported in a relaible study conducted according to appropriate protocol. The study is a read across from 1-icosanol (CAS 629-96-9).
Executive summary:

In an acute dermal toxicity study, the test material (icosan-1 -ol) was applied onto rabbit skin and kept in contact to the skin for 4 hours under occlusive dressing. There is lack of detail on the materials and methods used, as well as results, however the study reports an LD50 value of > 20 ml/kg (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). The study meets generally accepted scientific principles, acceptable for assessment. Study considered valid although result reporting is limited. The study is a read across from icosan-1-ol (CAS 629-96-9).