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EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
Pregnancy data: The duration of pregnancy was identical in all groups.
Litter data: No significant effects on litter size. The mean body weight of offspring of dams exposed to 1000 and 1200 ppm toluene was significantly lower at birth. The reduction of the offspring mean body weight remained until postnatal day 7 in the 1200 ppm group. There was a significantly higher mortality prior to weaning in the 1200 ppm group (7% v. 2.6%).
Postnatal development: Incisor eruption and vaginal opening were delayed at 1200 ppm. Vaginal opening was also delayed at 1000 ppm.
Fertility: No treatment-related effects.
Development of reflexes:There were no differences in the development of reflexes, rota rod performance and locomotor activity between the offspring of animals exposed to toluene and the controls.
Locomotor activity:There were no differences in locomotor activity between the offspring of animals exposed to toluene and the controls.
Discrimination learning: No concentration-dependent adverse effects were detected.
Developmental toxicity and post-natal development were assessed in groups of >20 pregnant female rats exposed to toluene via inhalation 6 h/day during gestation (days 9 -21). Exposure concentrations were 0, 300, 600, 1000 or 1200 ppm. A detailed evaluation of physical development of offspring was conducted and the following tests performed: fore-limb grasp reflex, righting reflex, cliff-drop aversion reflex, maintenance of balance on a rotating rod, locomotor activity, learning ability in a discrimination learning test.
Maternal toluene exposures of 1200 ppm resulted in a reduced body weight gain of rat dams and offspring had lower body weight at birth and day 7 and a higher mortality until weaning. Some developmental landmarks (incisor eruption and vaginal opening) were delayed in this group and are likely to be secondary to the effect on body weight. At 1000 ppm maternal body weight gain was low and offspring had low body weight at birth and delayed vaginal opening. 600 ppm (2261 mg/m3) is the NOAEC for both maternal toxicity and developmental toxicity.
There were no differences in the development of reflexes, rota rod performance and locomotor activity that were attributable to treatment with toluene and no effects were found on learning ability in the operant conditioning task. There were no differences in mating, fertility and pregnancy indexes in the F1-generation. 1200 ppm (4522 mg/m3) is the NOAEC for effects on offspring behaviour.
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