Registration Dossier

Ecotoxicological information

Toxicity to other above-ground organisms

Currently viewing:

Administrative data

Endpoint:
toxicity to other above-ground organisms
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guideline study with scientificallly defensible design, cobalt concentration not determined directly in feed.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Sixteen week dietary study with swine fed diet containing 4 dose levels of Co. 16 swine per treatment, growth assessed.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
COCl2 6H2O
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
not applicable

Sampling and analysis

Analytical monitoring:
no

Test substrate

Vehicle:
no

Test organisms

Test organisms (species):
other: swine
Details on test organisms:
3 way cross Hampshire x Yorkshire x Duroc

Study design

Study type:
extended laboratory study
Total exposure duration:
16 wk

Test conditions

Test temperature:
Not reported
Humidity:
Not reported
Photoperiod and lighting:
Not reported
Reference substance (positive control):
no

Results and discussion

Effect concentrations
Duration:
16 wk
Dose descriptor:
NOEC
Effect conc.:
200 mg/kg diet
Nominal / measured:
nominal
Conc. based on:
element
Basis for effect:
growth

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
A NOEC of 200 mg.kg diet resulted in no effect on swine growth after a minimum of 10 days of observation.